Design and Synthesis of Oligoamide‐Based Double α‐Helix Mimetics (Eur. J. Org. Chem. 17/2013)
Identifieur interne : 000010 ( Main/Exploration ); précédent : 000009; suivant : 000011Design and Synthesis of Oligoamide‐Based Double α‐Helix Mimetics (Eur. J. Org. Chem. 17/2013)
Auteurs : Oleg V. Kulikov [États-Unis] ; Sam Thompson ; Hai Xu [États-Unis] ; Christopher D. Incarvito [États-Unis] ; Richard T. W. Scott ; Ishu Saraogi [États-Unis] ; Laura Nevola [Espagne] ; Andrew D. Hamilton [États-Unis, Royaume-Uni]Source :
- European Journal of Organic Chemistry [ 1434-193X ] ; 2013-06.
English descriptors
Abstract
The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis‐oligobenzamide peptidomimetic; background: DNA chains. The xanthene‐linked bis‐oligobenzamide shown in the centre is an example of a super‐secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter‐helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff. Dr. Karl Harrison (Department of Chemistry, University of Oxford) is gratefully acknowledged for the production of the cover picture.
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DOI: 10.1002/ejoc.201390045
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Hamilton</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, Yale University, New Haven, CT 06511</wicri:regionArea><wicri:noRegion>CT 06511</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Organic Chemistry</title><title level="j" type="abbrev">Eur. J. Org. Chem.</title><idno type="ISSN">1434-193X</idno><idno type="eISSN">1099-0690</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2013-06">2013-06</date><biblScope unit="volume">2013</biblScope><biblScope unit="issue">17</biblScope><biblScope unit="page" from="/">n/a</biblScope><biblScope unit="page" to="/">n/a</biblScope></imprint><idno type="ISSN">1434-193X</idno></series><idno type="istex">DAE2B2A97F70C823076E34DE16DD67585D69D984</idno><idno type="DOI">10.1002/ejoc.201390045</idno><idno type="ArticleID">EJOC201390045</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1434-193X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amides</term><term>Helical structures</term><term>Hydrogen bonds</term><term>Peptidomimetics</term><term>Synthesis design</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The cover picture shows the binding of transcription factors to nucleic acids. Top left: multicomponent protein; bottom right: leucine zipper; centre: bis‐oligobenzamide peptidomimetic; background: DNA chains. The xanthene‐linked bis‐oligobenzamide shown in the centre is an example of a super‐secondary structural protein mimic. This work details the synthesis of oligobenzamide and oligopyridylamide strands connected through various spacers, allowing tuning of the inter‐helix angle and thus the potential nucleic acid or protein binding properties. Details are discussed in the article by A. D. Hamilton et al. on page 3427 ff. Dr. Karl Harrison (Department of Chemistry, University of Oxford) is gratefully acknowledged for the production of the cover picture.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Catalogne</li></region></list><tree><noCountry><name sortKey="Scott, Richard T W" sort="Scott, Richard T W" uniqKey="Scott R" first="Richard T. W." last="Scott">Richard T. W. 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